The RAS-RAF-MEK-ERK signaling pathway (MAPK signaling pathway) plays a significant role in multiple pathological behaviors and is most frequently dysregulated in more than 30% of human cancers.As key elements in this pathway, MEK1/2 play crucial roles in tumorigenesis and the inhibition of apoptosis, which makes their inhibition an attractive antit
As universities in Japan gain institutional autonomy in managing internal organizations, independent of governmental control as a result of deregulation and decentralizing reforms, it is becoming increasingly important that the executives and administrators of each institution demonstrate clear and strategic vision and ideas to external stakeholder
Wireless sensor networks have been widely adopted, and neighbor discovery is an essential step to construct the networks.Most existing studies on neighbor discovery are designed on the assumption that either all nodes are fully connected or only two nodes compose the network.However, networks are partially connected in reality: some nodes are withi
Invasive plants are non-native species that can spread rapidly, leading to detrimental economic, ecological, or environmental impact.In aquatic systems such as the Sacramento-San Joaquin River Delta in California, USA, management agencies use manned aerial vehicles (MAV) imaging spectroscopy missions to map and track annual changes in invasive aqua
Abstract Background Currently acoustic tag-detecting autonomous receivers must be visited periodically to download the files of tag detections.Hence, the information about the whereabouts of tagged fishes is not available to make prompt regulatory decisions to reduce entrainment.In contrast, real-time receivers can detect the signal from a transmit